The 6-Aminoquinolone WC5 Inhibits Different Functions of the Immediate-Early 2 (IE2) Protein of Human Cytomegalovirus That Are Essential for Viral Replication

The human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional factor essential for viral replication. IE2 modulates both viral and host gene expression, deregulates cell cycle progression, acts as an immunomodulator, and antagonizes cellular antiviral responses. Based on thes...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Mercorelli, Beatrice, Luganini, Anna, Muratore, Giulia, Massari, Serena, Terlizzi, Maria Elena, Tabarrini, Oriana, Gribaudo, Giorgio, Palù, Giorgio, Loregian, Arianna
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249379/
https://ncbi.nlm.nih.gov/pubmed/25155603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03309-14
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