The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein

WC5 is a 6-aminoquinolone that potently inhibits the replication of human cytomegalovirus (HCMV) but has no activity, or significantly less activity, against other herpesviruses. Here we investigated the nature of its specific anti-HCMV activity. Structure-activity relationship studies on a small se...

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Detalhes bibliográficos
Main Authors: Loregian, Arianna, Mercorelli, Beatrice, Muratore, Giulia, Sinigalia, Elisa, Pagni, Silvana, Massari, Serena, Gribaudo, Giorgio, Gatto, Barbara, Palumbo, Manlio, Tabarrini, Oriana, Cecchetti, Violetta, Palù, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863603/
https://ncbi.nlm.nih.gov/pubmed/20194695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01730-09
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