A 6-Aminoquinolone Compound, WC5, with Potent and Selective Anti-Human Cytomegalovirus Activity

We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of ∼500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was ∼10...

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Detalhes bibliográficos
Main Authors: Mercorelli, Beatrice, Muratore, Giulia, Sinigalia, Elisa, Tabarrini, Oriana, Biasolo, Maria Angela, Cecchetti, Violetta, Palù, Giorgio, Loregian, Arianna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2612181/
https://ncbi.nlm.nih.gov/pubmed/19015358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00988-08
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