Operon for Biosynthesis of Lipstatin, the Beta-Lactone Inhibitor of Human Pancreatic Lipase

Lipstatin, isolated from Streptomyces toxytricini as a potent and selective inhibitor of human pancreatic lipase, is a precursor for tetrahydrolipstatin (also known as orlistat, Xenical, and Alli), the only FDA-approved antiobesity medication for long-term use. Lipstatin features a 2-hexyl-3,5-dihyd...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Bai, Tingli, Zhang, Daozhong, Lin, Shuangjun, Long, Qingshan, Wang, Yemin, Ou, Hongyu, Kang, Qianjin, Deng, Zixin, Liu, Wen, Tao, Meifeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249243/
https://ncbi.nlm.nih.gov/pubmed/25239907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01765-14
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