Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis

Gram-positive Streptomyces bacteria produce thousands of bioactive secondary metabolites, including antibiotics. To systematically investigate genes affecting secondary metabolism, we developed a hyperactive transposase-based Tn5 transposition system and employed it to mutagenize the model species S...

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Detaylı Bibliyografya
Yayımlandı:Appl Environ Microbiol
Asıl Yazarlar: Xu, Zhong, Wang, Yemin, Chater, Keith F., Ou, Hong-Yu, Xu, H. Howard, Deng, Zixin, Tao, Meifeng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Genetics and Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335527/
https://ncbi.nlm.nih.gov/pubmed/28062460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02889-16
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