RedH and PigC Catalyze the Biosynthesis of Hybrubins via Phosphorylation of 4′-Methoxy-2,2′-Bipyrrole-5′-Carbaldehyde

Hybrubins are “unnatural” alkaloids with the same 4′-methoxy-2,2′-bipyrrole-5′-methine moiety found in prodiginines and a different ring derived from tetramic acids. Here, we demonstrated that RedH, a homologue of prodigiosin synthetase PigC, was responsible for the biosynthesis of hybrubins A and B...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Long, Qingshan, Jeffries, Daniel E., Lin, Shuangjun, Chen, Xuefei, He, Weijun, Wang, Yemin, Deng, Zixin, Lindsley, Craig W., Tao, Meifeng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Enzymology and Protein Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952227/
https://ncbi.nlm.nih.gov/pubmed/31704680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02331-19
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