Recombinant Modified Vaccinia Virus Ankara Generating Excess Early Double-Stranded RNA Transiently Activates Protein Kinase R and Triggers Enhanced Innate Immune Responses

Double-stranded RNA (dsRNA) is an important molecular pattern associated with viral infection and is detected by various extra- and intracellular recognition molecules. Poxviruses have evolved to avoid producing dsRNA early in infection but generate significant amounts of dsRNA late in infection due...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Wolferstätter, Michael, Schweneker, Marc, Späth, Michaela, Lukassen, Susanne, Klingenberg, Marieken, Brinkmann, Kay, Wielert, Ursula, Lauterbach, Henning, Hochrein, Hubertus, Chaplin, Paul, Suter, Mark, Hausmann, Jürgen
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Cellular Response to Infection
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249137/
https://ncbi.nlm.nih.gov/pubmed/25297997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02082-14
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