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Molecular Basis for Ebolavirus VP35 Suppression of Human Dendritic Cell Maturation

Zaire ebolavirus (EBOV) VP35 is a double-stranded RNA (dsRNA)-binding protein that inhibits RIG-I signaling and alpha/beta interferon (IFN-α/β) responses by both dsRNA-binding-dependent and -independent mechanisms. VP35 also suppresses dendritic cell (DC) maturation. Here, we define the pathways and...

詳細記述

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書誌詳細
出版年:J Virol
主要な著者: Yen, Benjamin, Mulder, Lubbertus C. F., Martinez, Osvaldo, Basler, Christopher F.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248944/
https://ncbi.nlm.nih.gov/pubmed/25142601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02163-14
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