Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual expression program within TEC populations and...

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Опубликовано в: :Genome Res
Главные авторы: Sansom, Stephen N., Shikama-Dorn, Noriko, Zhanybekova, Saule, Nusspaumer, Gretel, Macaulay, Iain C., Deadman, Mary E., Heger, Andreas, Ponting, Chris P., Holländer, Georg A.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2014
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248310/
https://ncbi.nlm.nih.gov/pubmed/25224068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.171645.113
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