SAR405838: An optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

Blocking the MDM2-p53 protein-protein interaction has long been considered to offer a broad cancer therapeutic strategy, despite the potential risks of selecting tumors harboring p53 mutations that escape MDM2 control. In this study, we report a novel small molecule inhibitor of the MDM2-p53 interac...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Wang, Shaomeng, Sun, Wei, Zhao, Yujun, McEachern, Donna, Meaux, Isabelle, Barrière, Cédric, Stuckey, Jeanne, Meagher, Jennifer, Bai, Longchuan, Liu, Liu, Hoffman-Luca, Cassandra Gianna, Lu, Jianfeng, Shangary, Sanjeev, Yu, Shanghai, Bernard, Denzil, Aguilar, Angelo, Dos-Santos, Odette, Besret, Laurent, Guerif, Stéphane, Pannier, Pascal, Gorge-Bernat, Dimitri, Debussche, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4247201/
https://ncbi.nlm.nih.gov/pubmed/25145672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0799
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