Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

To determine the role of glucagon action in diet-induced and genetic type 2 diabetes (T2D), we studied high-fat-diet–induced obese (DIO) and leptin receptor-defective (LepR(−/−)) rodents with and without glucagon receptors (GcgRs). DIO and LepR(−/−),GcgR(+/+) mice both developed hyperinsulinemia, in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Young, Berglund, Eric D., Yu, Xinxin, Wang, May-Yun, Evans, Matthew R., Scherer, Philipp E., Holland, William L., Charron, Maureen J., Roth, Michael G., Unger, Roger H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246985/
https://ncbi.nlm.nih.gov/pubmed/25157166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409638111
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados