HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

Cellular DNA repair processes are crucial to maintain genome stability and integrity. In DNA base excision repair, a tight heterodimer complex formed by DNA polymerase β (Polβ) and XRCC1 is thought to facilitate repair by recruiting Polβ to DNA damage sites. Here we show that disruption of the compl...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Fang, Qingming, Inanc, Burcu, Schamus, Sandy, Wang, Xiao-hong, Wei, Leizhen, Brown, Ashley R., Svilar, David, Sugrue, Kelsey F., Goellner, Eva M., Zeng, Xuemei, Yates, Nathan A., Lan, Li, Vens, Conchita, Sobol, Robert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246423/
https://ncbi.nlm.nih.gov/pubmed/25423885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6513
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