Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress

Protein–protein interactions regulate many essential enzymatic processes in the cell. Somatic mutations outside of an enzyme active site can therefore impact cellular function by disruption of critical protein–protein interactions. In our investigation of the cellular impact of the T304I cancer muta...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Fang, Qingming, Andrews, Joel, Sharma, Nidhi, Wilk, Anna, Clark, Jennifer, Slyskova, Jana, Koczor, Christopher A, Lans, Hannes, Prakash, Aishwarya, Sobol, Robert W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614843/
https://ncbi.nlm.nih.gov/pubmed/31287140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz293
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