Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome

Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown....

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hu, Qi, Wu, Di, Chen, Wen, Yan, Zhen, Yan, Chuangye, He, Tianxi, Liang, Qionglin, Shi, Yigong
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246342/
https://ncbi.nlm.nih.gov/pubmed/25313070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418000111
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