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Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme
Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of caspas...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5320974/ https://ncbi.nlm.nih.gov/pubmed/28143931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620626114 |
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