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Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme
Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of caspas...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5320974/ https://ncbi.nlm.nih.gov/pubmed/28143931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620626114 |
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