Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together forming a holoenzyme. The molecular mechanism of caspas...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Li, Yini, Zhou, Mengying, Hu, Qi, Bai, Xiao-chen, Huang, Weiyun, Scheres, Sjors H. W., Shi, Yigong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320974/
https://ncbi.nlm.nih.gov/pubmed/28143931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620626114
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