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Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1
The apoptotic protease-activating factor 1 (Apaf-1) controls the onset of many known forms of intrinsic apoptosis in mammals. Apaf-1 exists in normal cells as an autoinhibited monomer. Upon binding to cytochrome c and dATP, Apaf-1 oligomerizes into a heptameric complex known as the apoptosome, which...
Gespeichert in:
| Veröffentlicht in: | Genes Dev |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4691890/ https://ncbi.nlm.nih.gov/pubmed/26543158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.272278.115 |
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