Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

It recently has been recognized that men develop colonic adenomas and carcinomas at an earlier age and at a higher rate than women. In the Apc(Pirc/+) (Pirc) rat model of early colonic cancer, this sex susceptibility was recapitulated, with male Pirc rats developing twice as many adenomas as females...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Amos-Landgraf, James M., Heijmans, Jarom, Wielenga, Mattheus C. B., Dunkin, Elisa, Krentz, Kathy J., Clipson, Linda, Ederveen, Antwan G., Groothuis, Patrick G., Mosselman, Sietse, Muncan, Vanesa, Hommes, Daniel W., Shedlovsky, Alexandra, Dove, William F., van den Brink, Gijs R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246303/
https://ncbi.nlm.nih.gov/pubmed/25368192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323064111
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