Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones

It recently has been recognized that men develop colonic adenomas and carcinomas at an earlier age and at a higher rate than women. In the Apc(Pirc/+) (Pirc) rat model of early colonic cancer, this sex susceptibility was recapitulated, with male Pirc rats developing twice as many adenomas as females...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Amos-Landgraf, James M., Heijmans, Jarom, Wielenga, Mattheus C. B., Dunkin, Elisa, Krentz, Kathy J., Clipson, Linda, Ederveen, Antwan G., Groothuis, Patrick G., Mosselman, Sietse, Muncan, Vanesa, Hommes, Daniel W., Shedlovsky, Alexandra, Dove, William F., van den Brink, Gijs R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246303/
https://ncbi.nlm.nih.gov/pubmed/25368192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323064111
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