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Decreased polycystin 2 expression alters calcium-contraction coupling and changes β-adrenergic signaling pathways
Cardiac disorders are the main cause of mortality in autosomal-dominant polycystic kidney disease (ADPKD). However, how mutated polycystins predispose patients with ADPKD to cardiac pathologies before development of renal dysfunction is unknown. We investigate the effect of decreased levels of polyc...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4246301/ https://ncbi.nlm.nih.gov/pubmed/25368166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415933111 |
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