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The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function
Polycystin 2 (PC2) is a calcium-dependent calcium channel, and mutations to human PC2 (hPC2) are associated with polycystic kidney disease. The C-terminal tail of hPC2 contains 2 EF hand motifs, but only the second binds calcium. Here, we investigate whether these EF hand motifs serve as a calcium s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3986840/ https://ncbi.nlm.nih.gov/pubmed/24558196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247106 |
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