Calcium-induced Conformational Changes in C-terminal Tail of Polycystin-2 Are Necessary for Channel Gating

Polycystin-2 (PC2) is a Ca(2+)-permeable transient receptor potential channel activated and regulated by changes in cytoplasmic Ca(2+). PC2 mutations are responsible for ∼15% of autosomal dominant polycystic kidney disease. Although the C-terminal cytoplasmic tail of PC2 has been shown to contain a...

Full description

Saved in:
Bibliographic Details
Main Authors: Ćelić, Andjelka S., Petri, Edward T., Benbow, Jennifer, Hodsdon, Michael E., Ehrlich, Barbara E., Boggon, Titus J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366810/
https://ncbi.nlm.nih.gov/pubmed/22474326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.354613
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items