Structural Identification of the Vps18 β-Propeller Reveals a Critical Role in the HOPS Complex Stability and Function

Membrane fusion at the vacuole, the lysosome equivalent in yeast, requires the HOPS tethering complex, which is recruited by the Rab7 GTPase Ypt7. HOPS provides a template for the assembly of SNAREs and thus likely confers fusion at a distinct position on vacuoles. Five of the six subunits in HOPS h...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Behrmann, Heide, Lürick, Anna, Kuhlee, Anne, Balderhaar, Henning Kleine, Bröcker, Cornelia, Kümmel, Daniel, Engelbrecht-Vandré, Siegfried, Gohlke, Ulrich, Raunser, Stefan, Heinemann, Udo, Ungermann, Christian
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Membrane Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246104/
https://ncbi.nlm.nih.gov/pubmed/25324549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602714
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