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β-Apo-13-carotenone Regulates Retinoid X Receptor Transcriptional Activity through Tetramerization of the Receptor

Retinoid X receptor (RXRα) is activated by 9-cis-retinoic acid (9cRA) and regulates transcription as a homodimer or as a heterodimer with other nuclear receptors. We have previously demonstrated that β-apo-13-carotenone, an eccentric cleavage product of β-carotene, antagonizes the activation of RXRα...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Sun, Jian, Narayanasamy, Sureshbabu, Curley, Robert W., Harrison, Earl H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246072/
https://ncbi.nlm.nih.gov/pubmed/25324544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610501
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