Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.

Hypertriglyceridemia is a metabolic complication of retinoid therapy. In this study, we analyzed whether retinoids increase the expression of apo C-III, an antagonist of plasma triglyceride catabolism. In men, isotretinoin treatment (80 mg/d; 5 d) resulted in elevated plasma apo C-III, but not apo E...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Vu-Dac, N, Gervois, P, Torra, I P, Fruchart, J C, Kosykh, V, Kooistra, T, Princen, H M, Dallongeville, J, Staels, B
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508923/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9691099/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1581
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