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The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα

In this study, we investigated the effects of eccentric cleavage products of β-carotene, i.e. β-apocarotenoids (BACs), on retinoid X receptor alpha (RXRα) signaling. Transactivation assays were performed to test whether BACs activate or antagonize RXRα. Reporter gene constructs (RXRE-Luc, pRL-tk) an...

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Библиографические подробности
Главные авторы: Eroglu, Abdulkerim, Hruszkewycz, Damian P., Curley, Robert W., Harrison, Earl H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517194/
https://ncbi.nlm.nih.gov/pubmed/20678466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.07.025
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