Naturally Occurring Eccentric Cleavage Products of Provitamin A β-Carotene Function as Antagonists of Retinoic Acid Receptors

β-Carotene is the major dietary source of provitamin A. Central cleavage of β-carotene catalyzed by β-carotene oxygenase 1 yields two molecules of retinaldehyde. Subsequent oxidation produces all-trans-retinoic acid (ATRA), which functions as a ligand for a family of nuclear transcription factors, t...

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Autors principals: Eroglu, Abdulkerim, Hruszkewycz, Damian P., dela Sena, Carlo, Narayanasamy, Sureshbabu, Riedl, Ken M., Kopec, Rachel E., Schwartz, Steven J., Curley, Robert W., Harrison, Earl H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346154/
https://ncbi.nlm.nih.gov/pubmed/22418437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.325142
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