Polymerase η suppresses telomere defects induced by DNA damaging agents

Telomeres at chromosome ends are normally masked from proteins that signal and repair DNA double strand breaks (DSBs). Bulky DNA lesions can cause DSBs if they block DNA replication, unless they are bypassed by translesion (TLS) DNA polymerases. Here, we investigated roles for TLS polymerase η, (pol...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Pope-Varsalona, Hannah, Liu, Fu-Jun, Guzik, Lynda, Opresko, Patricia L.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245935/
https://ncbi.nlm.nih.gov/pubmed/25355508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1030
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