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Polymerase η suppresses telomere defects induced by DNA damaging agents

Telomeres at chromosome ends are normally masked from proteins that signal and repair DNA double strand breaks (DSBs). Bulky DNA lesions can cause DSBs if they block DNA replication, unless they are bypassed by translesion (TLS) DNA polymerases. Here, we investigated roles for TLS polymerase η, (pol...

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Pubblicato in:Nucleic Acids Res
Autori principali: Pope-Varsalona, Hannah, Liu, Fu-Jun, Guzik, Lynda, Opresko, Patricia L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245935/
https://ncbi.nlm.nih.gov/pubmed/25355508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1030
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