pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo

[Image: see text] We have developed an improved tool for imaging acidic tumors by reporting the insertion of a transmembrane helix: the pHLIP-Fluorescence Insertion REporter (pHLIP-FIRE). In acidic tissues, such as tumors, peptides in the pHLIP family insert as α-helices across cell membranes. The c...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Karabadzhak, Alexander G., An, Ming, Yao, Lan, Langenbacher, Rachel, Moshnikova, Anna, Adochite, Ramona-Cosmina, Andreev, Oleg A., Reshetnyak, Yana K., Engelman, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245173/
https://ncbi.nlm.nih.gov/pubmed/25184440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500388m
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