Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia

An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear. Microarrays of neural tissue of animal models of the disease showed decreases in antioxidant genes, and inc...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Hayashi, Genki, Shen, Yan, Pedersen, Theresa L., Newman, John W., Pook, Mark, Cortopassi, Gino
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245045/
https://ncbi.nlm.nih.gov/pubmed/25104852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu407
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