A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain and Ameliorates Hepatic Dysfunction in High-Fat–Fed Mice

We hypothesized that the mitochondrial-targeted antioxidant, mitoquinone (mitoQ), known to have mitochondrial uncoupling properties, might prevent the development of obesity and mitigate liver dysfunction by increasing energy expenditure, as opposed to reducing energy intake. We administered mitoQ o...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Fink, Brian D., Herlein, Judith A., Guo, Deng Fu, Kulkarni, Chaitanya, Weidemann, Benjamin J., Yu, Liping, Grobe, Justin L., Rahmouni, Kamal, Kerns, Robert J., Sivitz, William I.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244581/
https://ncbi.nlm.nih.gov/pubmed/25301169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.219329
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