Redesigning the DNA-Targeted Chromophore in Platinum–Acridine Anticancer Agents: A Structure–Activity Relationship Study

Platinum–acridine hybrid agents show low-nanomolar potency in chemoresistant non-small cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous genotoxicity of these agents and improve their pharmacological properties, a modular build–click–screen approach was used to...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Pickard, Amanda J., Liu, Fang, Bartenstein, Thomas F., Haines, Laura G., Levine, Keith E., Kucera, Gregory L., Bierbach, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244275/
https://ncbi.nlm.nih.gov/pubmed/25302716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201404845
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