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Design of Enzymatically Cleavable Prodrugs of a Potent Platinum-Containing Anticancer Agent
Using a versatile synthetic approach, a new class of potential ester prodrugs of highly potent, but systemically too toxic, platinum–acridine anticancer agents was generated. The new hybrids contain a hydroxyl group, which has been masked with a cleavable lipophilic acyl moiety. Both butanoic (butyr...
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| Publicado no: | Chemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4244258/ https://ncbi.nlm.nih.gov/pubmed/25303639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201404675 |
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