Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

The F-box protein Skp2 mediates c-Myc ubiquitylation by binding to the MB2 domain. However, the turnover of c-Myc is largely dependent on phosphorylation of threonine-58 and serine-62 in MB1, residues that are often mutated in cancer. We now show that the F-box protein Fbw7 interacts with and thereb...

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Bibliografiske detaljer
Main Authors: Yada, Masayoshi, Hatakeyama, Shigetsugu, Kamura, Takumi, Nishiyama, Masaaki, Tsunematsu, Ryosuke, Imaki, Hiroyuki, Ishida, Noriko, Okumura, Fumihiko, Nakayama, Keiko, Nakayama, Keiichi I
Format: Artigo
Sprog:Inglês
Udgivet: 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC424394/
https://ncbi.nlm.nih.gov/pubmed/15103331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600217
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