Early Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin

The Wnt signaling pathway plays a pivotal role in vertebrate early development and morphogenesis. Duplin (axis duplication inhibitor) interacts with β-catenin and prevents its binding to Tcf, thereby inhibiting downstream Wnt signaling. Here we show that Duplin is expressed predominantly from early-...

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Hlavní autoři: Nishiyama, Masaaki, Nakayama, Keiko, Tsunematsu, Ryosuke, Tsukiyama, Tadasuke, Kikuchi, Akira, Nakayama, Keiichi I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC516734/
https://ncbi.nlm.nih.gov/pubmed/15367660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8386-8394.2004
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