Effect of UGT1A1, UGT1A3, DIO1 and DIO2 polymorphisms on L-thyroxine doses required for TSH suppression in patients with differentiated thyroid cancer

AIM: To evaluate the impact of genetic polymorphisms in uridine 5′-glucuronosylytansferases UGT1A1 and UGT1A3 and iodothyronine-deiodinases types 1 and 2 on levothyroxine (T(4); 3,5,3′,5′-triiodo-L-thyronine) dose requirement for suppression of thyrotropin (TSH) secretion in patients with differenti...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Santoro, Ana B, Vargens, Daniela D, Barros Filho, Mateus de Camargo, Bulzico, Daniel A, Kowalski, Luiz Paulo, Meirelles, Ricardo M R, Paula, Daniela P, Neves, Ronaldo R S, Pessoa, Cencita N, Struchine, Claudio J, Suarez-Kurtz, Guilherme
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Pharmacogenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243881/
https://ncbi.nlm.nih.gov/pubmed/24910925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12437
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