A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans

BACKGROUND AND PURPOSE: Alvespimycin, a new generation of heat shock protein 90 (Hsp90) inhibitor in clinical trial, is a promising therapeutic agent for cancer. Pharmacokinetic models of alvespimycin would help in the understanding of drug disposition, predicting drug exposure and interpreting dose...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Hu, Zhe-Yi, Lu, Jingtao, Zhao, Yuansheng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2014
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243854/
https://ncbi.nlm.nih.gov/pubmed/24471734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12609
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