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A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans
BACKGROUND AND PURPOSE: Alvespimycin, a new generation of heat shock protein 90 (Hsp90) inhibitor in clinical trial, is a promising therapeutic agent for cancer. Pharmacokinetic models of alvespimycin would help in the understanding of drug disposition, predicting drug exposure and interpreting dose...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4243854/ https://ncbi.nlm.nih.gov/pubmed/24471734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12609 |
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