Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human

Deoxypodophyllotoxin (DPT) is a potential anti-tumor candidate prior to its clinical phase. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model consisting of 13 tissue compartments to predict DPT disposition in mouse, rat, monkey, and dog based on in vitro and in...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Chen, Yang, Zhao, Kaijing, Liu, Fei, Xie, Qiushi, Zhong, Zeyu, Miao, Mingxing, Liu, Xiaodong, Liu, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159431/
https://ncbi.nlm.nih.gov/pubmed/28018224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00488
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