Epigenetic programming during monocyte to macrophage differentiation and trained innate immunity

INTRODUCTION: Monocytes circulate in the bloodstream for up to 3–5 days. Concomitantly, immunological imprinting of either tolerance (immunosuppression) or trained immunity (innate immune memory) determines the functional fate of monocytes and monocyte-derived macrophages, as observed after infectio...

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Publié dans:Science
Auteurs principaux: Saeed, Sadia, Quintin, Jessica, Kerstens, Hindrik H.D., Rao, Nagesha A, Aghajanirefah, Ali, Matarese, Filomena, Cheng, Shih-Chin, Ratter, Jacqueline, Berentsen, Kim, van der Ent, Martijn A., Sharifi, Nilofar, Janssen-Megens, Eva M., Huurne, Menno Ter, Mandoli, Amit, van Schaik, Tom, Ng, Aylwin, Burden, Frances, Downes, Kate, Frontini, Mattia, Kumar, Vinod, Giamarellos-Bourboulis, Evangelos J, Ouwehand, Willem H, van der Meer, Jos W.M., Joosten, Leo A.B., Wijmenga, Cisca, Martens, Joost H.A., Xavier, Ramnik J., Logie, Colin, Netea, Mihai G., Stunnenberg, Hendrik G.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242194/
https://ncbi.nlm.nih.gov/pubmed/25258085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1251086
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