mTOR/HIF1α-mediated aerobic glycolysis as metabolic basis for trained immunity

Epigenetic reprogramming of myeloid cells by infection or vaccination, termed trained immunity, confers non-specific protection from secondary infections. We characterized genome-wide transcriptome and histone modification profiles of human monocytes trained with β-glucan and identified induced expr...

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Publicado no:Science
Main Authors: Cheng, Shih-Chin, Quintin, Jessica, Cramer, Robert A., Shepardson, Kelly M., Saeed, Sadia, Kumar, Vinod, Giamarellos-Bourboulis, Evangelos J, Martens, Joost H.A., Rao, Nagesha Appukudige, Aghajanirefah, Ali, Manjeri, Ganesh R., Li, Yang, Ifrim, Daniela C., Arts, Rob J.W., van der Meer, Brian M.J.W., Deen, Peter M.T., Logie, Colin, O’Neill, Luke A., Willems, Peter, van de Veerdonk, Frank L., van der Meer, Jos W.M., Ng, Aylwin, Joosten, Leo A.B., Wijmenga, Cisca, Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226238/
https://ncbi.nlm.nih.gov/pubmed/25258083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250684
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