mTOR/HIF1α-mediated aerobic glycolysis as metabolic basis for trained immunity

Epigenetic reprogramming of myeloid cells by infection or vaccination, termed trained immunity, confers non-specific protection from secondary infections. We characterized genome-wide transcriptome and histone modification profiles of human monocytes trained with β-glucan and identified induced expr...

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Pubblicato in:Science
Autori principali: Cheng, Shih-Chin, Quintin, Jessica, Cramer, Robert A., Shepardson, Kelly M., Saeed, Sadia, Kumar, Vinod, Giamarellos-Bourboulis, Evangelos J, Martens, Joost H.A., Rao, Nagesha Appukudige, Aghajanirefah, Ali, Manjeri, Ganesh R., Li, Yang, Ifrim, Daniela C., Arts, Rob J.W., van der Meer, Brian M.J.W., Deen, Peter M.T., Logie, Colin, O’Neill, Luke A., Willems, Peter, van de Veerdonk, Frank L., van der Meer, Jos W.M., Ng, Aylwin, Joosten, Leo A.B., Wijmenga, Cisca, Stunnenberg, Hendrik G., Xavier, Ramnik J., Netea, Mihai G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226238/
https://ncbi.nlm.nih.gov/pubmed/25258083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250684
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