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Anti-tumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding

Calix[4]arene compound 0118 is an angiostatic agent that inhibits tumor growth in mice. Although 0118 is a topomimetic of galectin-1-targeting angiostatic amphipathic peptide anginex, we had yet to prove that 0118 targets galectin-1. Galectin-1 is involved in pathological disorders like tumor endoth...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Dings, Ruud P.M., Miller, Michelle C., Nesmelova, Irina, Astorgues-Xerri, Lucile, Kumar, Nigam, Serova, Maria, Chen, Xuimei, Raymond, Eric, Hoye, Thomas R., Mayo, Kevin H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242090/
https://ncbi.nlm.nih.gov/pubmed/22575017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300014q
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