TOPOMIMETICS OF AMPHIPATHIC β-SHEET AND HELIX-FORMING BACTERICIDAL PEPTIDES NEUTRALIZE LIPOPOLYSACCHARIDE ENDOTOXINS

Release of lipopolysaccharide (LPS) endotoxin from Gram negative bacterial membranes triggers macrophages to produce large quantities of cytokines that can lead to septic shock and eventual death. Agents that bind to and neutralize LPS may provide a means to clinically prevent septic shock upon bact...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Chen, Xuemei, Dings, Ruud P.M., Nesmelova, Irina, Debbert, Stefan, Haseman, Judith R., Maxwell, Jacques, Hoye, Thomas R., Mayo, Kevin H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242098/
https://ncbi.nlm.nih.gov/pubmed/17181157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0610447
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