Beta-sheet is the bioactive conformation of the anti-angiogenic anginex peptide.

Anginex is a designed peptide 33mer that functions as a cytokine-like agent to inhibit angiogenesis. Although this short linear peptide has been shown by NMR and CD to form a nascent beta-sheet conformation in solution, the actual bioactive structure formed upon binding to its receptor on the surfac...

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Bibliographic Details
Main Authors: Dings, Ruud P M, Arroyo, Monica M, Lockwood, Nathan A, van Eijk, Loes I, Haseman, Judy R, Griffioen, Arjan W, Mayo, Kevin H
Format: Artigo
Language:Inglês
Published: 2003
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223486/
https://ncbi.nlm.nih.gov/pubmed/12708970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030295
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