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Ablation of Tak1 in osteoclast progenitor leads to defects in skeletal growth and bone remodeling in mice
Tak1 is a MAPKKK that can be activated by growth factors and cytokines such as RANKL and BMPs and its downstream pathways include NF-κB and JNK/p38 MAPKs. Tak1 is essential for mouse embryonic development and plays critical roles in tissue homeostasis. Previous studies have shown that Tak1 is a posi...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4241509/ https://ncbi.nlm.nih.gov/pubmed/25418008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07158 |
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