Ablation of Gsα signaling in osteoclast progenitor cells adversely affects skeletal bone maintenance

Gsα, the alpha stimulatory subunit of heterotrimeric G proteins that activates downstream signaling through the adenylyl cyclase and cAMP/PKA pathway, plays an important role in bone development and remodeling. The role of Gsα in mesenchymal stem cell (MSC) differentiation to osteoblasts has been de...

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Vydáno v:Bone
Hlavní autoři: Ramaswamy, Girish, Fong, John, Brewer, Niambi, Kim, Hyunsoo, Zhang, Deyu, Choi, Yongwon, Kaplan, Frederick S., Shore, Eileen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866199/
https://ncbi.nlm.nih.gov/pubmed/29183785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.11.019
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