SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation

Methamphetamine (METH) exposure results in dopaminergic neurotoxicity in striatal regions of the brain, an effect that has been linked to an increased risk of Parkinson's disease. Various aspects of neuroinflammation, including astrogliosis, are believed to be contributory factors in METH neuro...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Robson, Matthew J., Turner, Ryan C., Naser, Zachary J., McCurdy, Christopher R., O'Callaghan, James P., Huber, Jason D., Matsumoto, Rae R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241368/
https://ncbi.nlm.nih.gov/pubmed/24508558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2014.01.020
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