Synthesis and Pharmacological Characterization of a Novel Sigma Receptor Ligand with Improved Metabolic Stability and Antagonistic Effects Against Methamphetamine

Methamphetamine interacts with sigma receptors at physiologically relevant concentrations suggesting a potential site for pharmacologic intervention. In the present study, a previous sigma receptor ligand, CM156, was optimized for metabolic stability, and the lead analog was evaluated against the be...

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Autors principals: Seminerio, Michael J., Robson, Matthew J., Abdelazeem, Ahmed H., Mesangeau, Christophe, Jamalapuram, Seshulatha, Avery, Bonnie A., McCurdy, Christopher R., Matsumoto, Rae R.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291180/
https://ncbi.nlm.nih.gov/pubmed/22183188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9311-8
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