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CRF neurons in the ventral tegmental area control the aversive effects of nicotine withdrawal and promote escalation of nicotine intake

Dopaminergic neurons in the ventral tegmental area (VTA) are well known for their role in mediating the positive reinforcing effects of drugs of abuse. Here, we identify in rodents and humans a population of VTA dopamine neurons co-expressing corticotropin releasing factor (CRF). We provide further...

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Détails bibliographiques
Publié dans:Nat Neurosci
Auteurs principaux: Grieder, Taryn E., Herman, Melissa A., Contet, Candice, Tan, Laura A., Vargas-Perez, Hector, Cohen, Ami, Chwalek, Michal, Maal-Bared, Geith, Freiling, John, Schlosburg, Joel E, Clarke, Laura, Crawford, Elena, Koebel, Pascale, Canonigo, Vez, Sanna, Pietro, Tapper, Andrew, Roberto, Marisa, Kieffer, Brigitte L., Sawchenko, Paul E., Koob, George F., van der Kooy, Derek, George, Olivier
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241147/
https://ncbi.nlm.nih.gov/pubmed/25402857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3872
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